COVID19 in children: 2 very recent papers
Dr. Albert Yan (Chief of Pediatric Dermatology Children’s Hospital of Philadelphia) As to why kids are less severe than adult centers on the relative immaturity of ACE2 in children, which is presumed to be the cell-receptor for the virus based on its similarity to the previous SARS virus. This relative immaturity may make children less receptive hosts for the virus. Take home points: Regarding Table 1 (Below): Additional pediatric data from a cohort of 171 children <10yo with confirmed SARS-CoV2 showed a surprisingly high rate of asymptomatic infection (16%). Of those infected there was a strikingly high proportion who developed pneumonia (65%). Between 76-90% had a relative with confirmed infection highlighting the likelihood of intra-familial spread.
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J Peds
https://drive.google.com/file/d/1YdaGs9-lrV51sFrDYIY_QZrt5MsdKocv/view?usp=drivesdk
COVID in children, Dong et al.
In this large pediatric case series based in China that involved over 2100 children, several important observations were noted:
NEJM article March 18, 2020:
https://www.nejm.org/doi/full/10.1056/NEJMc2005073