Neal Bhatia, MD & Ted Rosen, MD
- New drug for papulo-pustular rosacea: QD 1% ivermectin cream (Soolantra®, 30g tube)
- Better than placebo and superior to metronidazole 0.75% BID
- “Clear” or “Almost clear” by IGA : 38-40%
- New HPV vaccine (Gardasil 9®)
- Contains VLP to prior quadrivalent vaccine (HPV 6,11,16,18)
- PLUS: contains VLP to immunize against HPV 31,33,45,52,58
- Now 97% protective against genital SCCA due to 90% etiologic HPV
- Also recommended for MSM, where ~75% protective against anal SCCA
- Miltefosine (Impavido®) for leishmaniasis
- Both old world and new world organisms (more evidence for new world)
- 100-150mg daily (higher dose if over 45kg weight)
- AEs: anorexia, nausea, vomiting, diarrhea, H/A, mild ↑ LFTs, mild ↑Cr, and mild thrombocytopenia; but is Pregnancy category X (contraindicated): Do not take if pregnant, use adequate contraception during Rx and for five months after therapy has been discontinued
- Biologics are coming for atopic dermatitis
- Duplilumab (anti IL4, IL13)
- Lebrikizimab (anti IL13)
- Mepolizumab (anti IL5)
- Various anti IL31 monoclonal antibodies
- Watch for Vitamin D deficiency in various derm diseases: psoriasis, SLE, hidradenitis, alopecia areata; Not known if repletion of Vitamin D will be therapeutic
- Tofacitinib, a JAK3 janus kinase inhibitor, currently approved for RA, may be effective in psoriasis and psoriatic arthritis. A case report appeared showing benefit in alopecia totalis!
- Adalimumab appears beneficial for hidradenitis in a Phase III RCT.
- Dosage 40mg weekly
- Still not a miracle drug
- Tonsillectomy improved refractory psoriasis!
- Red henna tattoo does NOT affect pulse oximetry
- RUSHING to put on condoms leads to errors and failures, including increased STDs
