HCQ vs chloroquine in vitro activity against SARS-CoV-2 and rationale for using HCQ in COVID19 confirmed cases.
In vitro HCQ vs chloroquine testing on viral inhibition and dosing:
Dr. George Martin: The results of this in-vitro cell culture experiment suggest that hydroxychloroquine works better at inhibiting SARS-CoV-2 than chloroquine. The dose that was modelled and suggested is: 400 bid x 1 day and 200 mg bid x 4 days (note the differing dose compared to the French Study above)
What would I do as prophylaxis IF I was working with an ICU full of COVID 19 patients?
Dr. George Martin commentary: Given the 50 years of safety data of HCQ used as a DMARD in rheumatology for RA, SLE/DLE and dermatomyositis, I would do the following:
- HCQ 200 mg BID or TID…indefinitely until the virus passes. (would stop my statin – neuropathy risk)
- Zinc supplementation
- Zycam intranasal spray to hopefully minimize nasopharyngeal colonization in a manner similar to influenza virus